Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide

Base Information

Chemical Name:Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide
CAS No.:1279106-55-6
Molecular Formula:C₂₃H₁₈F₂N₂O₄S
Molecular Weight:456.47
Hs Code.:

Synonyms:Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide

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Chemical Property of Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide

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Technology Process of Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide

There total 6 articles about Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1279106-54-5
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid

: 78191-00-1
N-Methoxy-N-methylacetamide

: 1279106-55-6
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide

Guidance literature:: Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid; N-Methoxy-N-methylacetamide; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1188072-92-5
5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279106-55-6
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 25 °C

2.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / 12 h / 80 °C / 11377.6 Torr / Inert atmosphere; Autoclave

3.1: lithium hydroxide dihydrate; water / tetrahydrofuran; methanol / 6 h / 20 °C

3.2: pH 1

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 16 h / 20 °C

With dmap; lithium hydroxide dihydrate; 1,3-bis-(diphenylphosphino)propane; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1279106-52-3
Benzenesulfonyl-5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279106-55-6
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indole-5-carboxylic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / 12 h / 80 °C / 11377.6 Torr / Inert atmosphere; Autoclave

2.1: lithium hydroxide dihydrate; water / tetrahydrofuran; methanol / 6 h / 20 °C

2.2: pH 1

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 16 h / 20 °C

With dmap; lithium hydroxide dihydrate; 1,3-bis-(diphenylphosphino)propane; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;