(S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide

Base Information

• Chemical Name: (S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide
• CAS No.: 1173178-36-3
• Molecular Formula: C₁₃H₁₆F₃NO₂
• Molecular Weight: 275.271
• Mol file: 1173178-36-3.mol

Synonyms:(S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide

Chemical Property of (S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide

There total 1 articles about (S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-3-trifluoromethylbutanoic acid (348-75-4,162878-31-1) + D-2-phenylglycinol (56613-80-0) → (S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide (1173178-36-3) + (R)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide (1189770-31-7)

Guidance literature:

With HATU; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h; optical yield given as %de;

DOI:10.1021/jo900654y

Reference yield:

(S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide (1173178-36-3) → (R)-4-phenyl-2-((S)-3,3,3-trifluoro-2-methylpropyl)-4,5-dihydrooxazole (1173178-12-5) + (R)-4-phenyl-2-((R)-3,3,3-trifluoro-2-methylpropyl)-4,5-dihydrooxazole

Guidance literature:

(S)-4,4,4-trifluoro-N-((R)-2-hydroxy-1-phenylethyl)-3-methylbutanamide; With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 1h;

With potassium carbonate; In dichloromethane; at -78 - 20 ℃; for 1.5h; optical yield given as %de;

DOI:10.1021/jo900654y

upstream raw materials:

(-)-3-trifluoromethylbutanoic acid

D-2-phenylglycinol

Downstream raw materials:

(R)-4-phenyl-2-((S)-3,3,3-trifluoro-2-methylpropyl)-4,5-dihydrooxazole