(R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Base Information

Chemical Name:(R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate
CAS No.:1263944-53-1
Molecular Formula:C₂₅H₂₁BrF₃N₃O₂
Molecular Weight:532.36
Hs Code.:

Synonyms:(R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Chemical Property of (R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Technology Process of (R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

There total 4 articles about (R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264294-88-3
ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-49-5
(S)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-53-1
(R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: ChiralPak AD column; In methanol; ethanol; hexane; Resolution of racemate;

Reference yield:

: 1264296-05-0
ethyl 2-benzyl-5-(dimethylamino)-2-methyl-3-oxopent-4-enoate

: 1263944-49-5
(S)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-53-1
(R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide / chloroform / 2 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; ethanol / 0.33 h / 160 °C / Irradiation with microwave

3: ChiralPak AD column / hexane; ethanol; methanol / Resolution of racemate

With hydrogenchloride; N-chloro-succinimide; ChiralPak AD column; In 1,4-dioxane; methanol; ethanol; hexane; chloroform;

Reference yield:

: ethyl 2-benzyl-4-chloro-5-(dimethylamino)-2-methyl-3-oxopent-4-enoate

: 1263944-49-5
(S)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-53-1
(R)-ethyl 2-(6-bromo-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; ethanol / 0.33 h / 160 °C / Irradiation with microwave

2: ChiralPak AD column / hexane; ethanol; methanol / Resolution of racemate

With hydrogenchloride; ChiralPak AD column; In 1,4-dioxane; methanol; ethanol; hexane;