1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

Base Information

Chemical Name:1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one
CAS No.:1369391-49-0
Molecular Formula:C₄₂H₆₀O₂Si
Molecular Weight:625.023
Hs Code.:

1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

Synonyms:1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

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Chemical Property of 1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

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Technology Process of 1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

There total 4 articles about 1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

: 1369391-46-7
(3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-N-methoxy-N,10,13-trimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxamide

: 626-88-0
1-bromo-5-methylpentane

: 1369391-49-0
1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

Guidance literature:: 1-bromo-5-methylpentane; With magnesium; In tetrahydrofuran; at 45 ℃; for 2h; Inert atmosphere;

(3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-N-methoxy-N,10,13-trimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxamide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201478e

Reference yield:

: 1360163-54-7
(3S,10R,13S,17S)-3-hydroxy-N-methoxy-N,10,13-trimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxamide

: 1369391-49-0
1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-methyl-1H-imidazole; iodine / tetrahydrofuran / 20 °C

2.1: magnesium / tetrahydrofuran / 2 h / 45 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; iodine; magnesium; In tetrahydrofuran; 2.1: Grignard reaction / 2.2: Grignard reaction;
DOI:10.1021/jm201478e

Reference yield:

: 15173-68-9,10325-79-8
etienic acid

: 1369391-49-0
1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-methylhexan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: 1-methyl-1H-imidazole; iodine / tetrahydrofuran / 20 °C

3.1: magnesium / tetrahydrofuran / 2 h / 45 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; iodine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 3.1: Grignard reaction / 3.2: Grignard reaction;
DOI:10.1021/jm201478e