Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Base Information

Chemical Name:Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat
CAS No.:127027-95-6
Molecular Formula:C₂₃H₂₄N₂O₅
Molecular Weight:408.454
Hs Code.:

Synonyms:Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

There total 16 articles about Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 108-24-7
acetic anhydride

: Ethyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

: 127027-95-6
Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Guidance literature:: With sodium acetate; at 70 ℃; for 2.5h;
DOI:10.1002/hlca.19890720717

Reference yield:

: 70837-67-1
1-Acetyl-2,3-dihydro-7-hydroxy-6-methoxy-5-nitroindol

: 127027-95-6
Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / K₂CO₃, KI / dimethylformamide / 1.5 h / 80 °C

2: 80 percent / hydrogen / 5 percent Pd/C / tetrahydrofuran / 10 h / Ambient temperature

3: 1.) NaNO₂, HCl, 2.) NaOH, 3.) HCCOH / 1.) H₂O, 0 deg C, 2.) H₂O/EtOH, 3 h, 10 deg C; 8 h, room temperature, 3.) 75 deg C, 5 h

With hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; potassium iodide; hydroxy acetylene; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19890720717

Reference yield:

: 70837-65-9
(1-Acetyl-2,3-dihydro-6-methoxyindol-7-yl)-acetat

: 127027-95-6
Ethyl-3-acetyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / 100 percent HNO₃, Ac₂O / 0.67 h / 0 °C

2: 89 percent / NaOH / ethanol / 1 h / 10 °C

3: 99 percent / K₂CO₃, KI / dimethylformamide / 1.5 h / 80 °C

4: 80 percent / hydrogen / 5 percent Pd/C / tetrahydrofuran / 10 h / Ambient temperature

5: 1.) NaNO₂, HCl, 2.) NaOH, 3.) HCCOH / 1.) H₂O, 0 deg C, 2.) H₂O/EtOH, 3 h, 10 deg C; 8 h, room temperature, 3.) 75 deg C, 5 h

With hydrogenchloride; sodium hydroxide; hydrogen; nitric acid; acetic anhydride; potassium carbonate; potassium iodide; hydroxy acetylene; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19890720717