Technology Process of (S)-2-(amino(naphthalen-2-yl)methyl)phenol
There total 4 articles about (S)-2-(amino(naphthalen-2-yl)methyl)phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate;
In
benzene;
at 50 ℃;
for 72h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Sealed tube;
DOI:10.1002/chem.201101694
- Guidance literature:
-
With
titanium(IV) isopropylate; Ru[(S)-SegPhos](OAc)2; ammonium acetate; hydrogen;
In
methanol;
at 80 ℃;
for 24h;
under 38002.6 Torr;
enantioselective reaction;
Autoclave;
DOI:10.1002/anie.201915459
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / -10 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
3.1: ammonium acetate; hydrogen; titanium(IV) isopropylate; Ru[(S)-SegPhos](OAc)2 / methanol / 24 h / 80 °C / 38002.6 Torr / Autoclave
With
titanium(IV) isopropylate; Ru[(S)-SegPhos](OAc)2; ammonium acetate; hydrogen; isopropylmagnesium chloride; sodium hydride;
In
tetrahydrofuran; methanol; mineral oil;
DOI:10.1002/anie.201915459
