4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:217965-29-2
Molecular Formula:C₃₈H₄₅N₃O₈
Molecular Weight:671.791
Hs Code.:

4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Synonyms:4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 130096-70-7
L-2-<<(benzyloxy)carbonyl>amino>-3-butenoic acid benzyl ester

: 4-{2-[4-(Hydroxyimino-methyl)-phenoxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

: 217965-29-2
4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hypochlorite; In dichloromethane; for 22h; Ambient temperature;
DOI:10.1021/jm960626t

Reference yield:

: 217965-29-2
4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 4-(2-{4-[5-((S)-Benzyloxycarbonylamino-carboxy-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; for 5h; Yield given; Ambient temperature;
DOI:10.1021/jm960626t

Reference yield:

: 217965-29-2
4-(2-{4-[5-((S)-Benzyloxycarbonyl-benzyloxycarbonylamino-methyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: (S)-Benzyloxycarbonylamino-{3-[4-(2-piperidin-4-yl-ethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-acetic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.5 M LiOH / tetrahydrofuran / 5 h / Ambient temperature

2: 79 percent / CH₂Cl₂ / 1 h / Ambient temperature

With lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960626t