3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,2,4-dioxo-,(1alpha,5alpha,6alpha)-(9CI)

Base Information

Chemical Name:3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,2,4-dioxo-,(1alpha,5alpha,6alpha)-(9CI)
CAS No.:187681-87-4
Molecular Formula:C₆H₄O₅
Molecular Weight:156.095
Hs Code.:
Mol file:187681-87-4.mol

Synonyms:3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,2,4-dioxo-,(1alpha,5alpha,6alpha)-(9CI)

Suppliers and Price of 3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,2,4-dioxo-,(1alpha,5alpha,6alpha)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,2,4-dioxo-,(1alpha,5alpha,6alpha)-(9CI)

Chemical Property:

PSA：80.67000
LogP:-0.98340

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,2,4-dioxo-,(1alpha,5alpha,6alpha)-(9CI)

There total 2 articles about 3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,2,4-dioxo-,(1alpha,5alpha,6alpha)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 705-35-1
trans,meso-1,2,3-cyclopropanetricarboxylic acid

: 187681-87-4
(1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: With acetic anhydride; In acetic acid; for 2h; Reflux; Large scale reaction;
DOI:10.1021/op200174k

Reference yield:

: 13949-99-0
trans,meso-cyclopropanetricarboxylic acid triethyl ester

: 187681-87-4
(1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 50 °C / Reflux; Large scale reaction

2: acetic anhydride / acetic acid / 2 h / Reflux; Large scale reaction

With acetic anhydride; sodium hydroxide; In ethanol; acetic acid;
DOI:10.1021/op200174k

Reference yield:

: 187681-87-4
(1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid

: 100-46-9
benzylamine

: 1366657-90-0,185542-78-3
(1R,5S,6r)-3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: (1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid; benzylamine; With triethylamine; In acetone; at 20 ℃; for 3h; Large scale reaction;

With sodium acetate; acetic anhydride; for 1h; Reflux; Large scale reaction;
DOI:10.1021/op200174k