methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate

Base Information

Chemical Name:methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate
CAS No.:146827-58-9
Molecular Formula:C₁₉H₂₄N₂O₄S
Molecular Weight:376.477
Hs Code.:

Synonyms:methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate

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Chemical Property of methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate

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Technology Process of methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate

There total 1 articles about methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 5638-76-6
betahistine

: 135934-36-0
methyl 2-benzyl-3-(chlorosulfonyl)propionate

: 146827-58-9
methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate

Guidance literature:: With triethylamine; In dichloromethane; at -10 ℃; for 0.5h;
DOI:10.1021/jm00056a006

Reference yield: 85.0%

: 146827-58-9
methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate

: 136010-57-6
2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water; at 0 ℃; for 1.5h;
DOI:10.1021/jm00056a006

Reference yield:

: 146827-58-9
methyl 2-benzyl-3-<<(2-pyridin-2-ylethyl)methylamino>sulfonyl>propionate

: (S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-3-[methyl-(2-pyridin-2-yl-ethyl)-sulfamoyl]-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LiOH*H₂O / dioxane; H₂O / 1.5 h / 0 °C

2: 1-hydroxybenzotriazole, N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 14 h

With 4-methyl-morpholine; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00056a006