(2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

Base Information

Chemical Name:(2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid
CAS No.:125782-37-8
Molecular Formula:C₂₁H₂₅NO₅
Molecular Weight:371.433
Hs Code.:

Synonyms:(2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

Suppliers and Price of (2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

Chemical Property:

Purity/Quality:: 99.00% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

There total 10 articles about (2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 125782-48-1
(1'R,4S,5R)-5-<2'-<(4''-benzoylbenzyl)oxy>-1'-methylethyl>-3-methyl-2-oxooxazolidine-4-carboxylic acid

: 125782-37-8
(2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

Guidance literature:: With potassium hydroxide; for 6h; Heating;
DOI:10.1021/jm00167a026

Reference yield:

: 114762-43-5
(4S,2Z)-5-(benzyloxy)-4-methyl-2-penten-1-ol

: 125782-37-8
(2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 92.3 percent / mCPBA / CH₂Cl₂ / 1.) -10 deg C, 1 h, 2.) 0 deg C, 1.5 h

2: 93 percent / Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

3: 84 percent / sodium hydride / tetrahydrofuran / 5.5 h

4: imidazole / dimethylformamide / 6 h / Ambient temperature

5: H₂ / palladium hydroxide on carbon / ethanol / 1.5 h

6: KH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temp., 1 h

7: Bu₄NF / tetrahydrofuran / 0.67 h / 0 °C

8: 81 percent / Jones reagent / acetone / 1 h

9: 50 percent / 2 N aq. KOH / 6 h / Heating

With 1H-imidazole; potassium hydroxide; jones reagent; tetrabutyl ammonium fluoride; hydrogen; potassium hydride; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00167a026

Reference yield:

: 125782-40-3
(1'R,4R,5R)-5-<2'-(benzyloxy)-1'-methylethyl>-4-(hydroxymethyl)-3-methyl-2-oxazolidinone

: 125782-37-8
(2S,3R,4R)-5-<(4'-benzoylbenzyl)oxy>-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 6 h / Ambient temperature

2: H₂ / palladium hydroxide on carbon / ethanol / 1.5 h

3: KH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temp., 1 h

4: Bu₄NF / tetrahydrofuran / 0.67 h / 0 °C

5: 81 percent / Jones reagent / acetone / 1 h

6: 50 percent / 2 N aq. KOH / 6 h / Heating

With 1H-imidazole; potassium hydroxide; jones reagent; tetrabutyl ammonium fluoride; hydrogen; potassium hydride; palladium dihydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00167a026