1-(4-Trifluoromethoxyphenyl)piperazine

Base Information

• Chemical Name: 1-(4-Trifluoromethoxyphenyl)piperazine
• CAS No.: 187669-62-1
• Molecular Formula: C11H13 F3 N2 O
• Molecular Weight: 246.232
• Mol file: 187669-62-1.mol

Synonyms:1-(4-Trifluoromethoxyphenyl)piperazine;4-(4-Trifluoromethoxyphenyl)piperazine

Chemical Property of 1-(4-Trifluoromethoxyphenyl)piperazine

Chemical Property:

• Vapor Pressure: 0.000677mmHg at 25°C
• Refractive Index: 1.486
• Boiling Point: 308.5°Cat760mmHg
• Flash Point: 140.4°C
• PSA: 24.50000
• Density: 1.242g/cm³
• LogP: 2.38860

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Trifluoromethoxy-phenyl)-piperazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Trifluoromethoxyphenyl)piperazine

There total 6 articles about 1-(4-Trifluoromethoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4-(trifluoromethoxy)phenyl)piperazine hydrochloride (490030-46-1) → 1-(4-(trifluoromethoxy)phenyl)piperazine (187669-62-1)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.5h; pH=11 - 12;

DOI:10.1111/cbdd.13324

Reference yield: 91.0%

tert-butyl 4-(4-(trifluoromethyl)-phenyl)-piperazine-1-carboxylate (490030-45-0) → 1-(4-(trifluoromethoxy)phenyl)piperazine (187669-62-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h; Cooling with ice;

Reference yield: 62.0%

4-(trifluoromethoxy)aniline (461-82-5) + bis-(2-chloroethyl)amine hydrochloride (821-48-7) → 1-(4-(trifluoromethoxy)phenyl)piperazine (187669-62-1)

Guidance literature:

at 20 - 165 ℃; neat (no solvent);

DOI:10.2174/157017811799304386

upstream raw materials:

1-bromo-4-(trifluoromethoxy)benzene

piperazine

4-(trifluoromethoxy)aniline

bis-(2-chloroethyl)amine hydrochloride

Downstream raw materials:

(S)-1-(2-chloro-4-nitroimidazol-1-yl)-2-methyl-3-[4-(4-trifluoromethoxyphenyl)piperazin-1-yl]propan-2-ol

carbamic acid 1-phenyl-3-[4-(4-trifluoromethoxy-phenyl)-piperazin-1-yl]-propyl ester

C₂₀H₂₃F₃N₂O₂

C₂₀H₂₁F₃N₂O₂

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