4-Piperazin-1-yl-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 4-Piperazin-1-yl-benzoic acid tert-butyl ester
• CAS No.: 187669-28-9
• Molecular Formula: C15H22 N2 O2
• Molecular Weight: 262.352
• Mol file: 187669-28-9.mol

Synonyms:4-Piperazin-1-yl-benzoic acid tert-butyl ester

Chemical Property of 4-Piperazin-1-yl-benzoic acid tert-butyl ester

Chemical Property:

• Vapor Pressure: 1.17E-06mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 401.6°Cat760mmHg
• Flash Point: 196.7°C
• Density: 1.069g/cm³

Purity/Quality:

99%+, ^*data from raw suppliers

tert-Butyl 4-(piperazin-1-yl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperazin-1-yl-benzoic acid tert-butyl ester

There total 1 articles about 4-Piperazin-1-yl-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

piperazine (110-85-0) + tert-butyl 4-fluorobenzoate (58656-98-7) → tert-butyl 4-(piperazin-1-yl)benzoate (187669-28-9)

Guidance literature:

In dimethyl sulfoxide; at 20 - 120 ℃;

DOI:10.1039/c0cc02969f

Reference yield: 75.0%

tert-butyl 4-(piperazin-1-yl)benzoate (187669-28-9) + 4-Bromo-2-methylphenol (2362-12-1) → tert-butyl 4-(4-(4-hydroxy-3-methylphenyl)piperazin-1-yl)benzoate

Guidance literature:

With methanesulfonato(2-dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl)(2’-methylamino-1,1‘-biphenyl-2-yl)palladium(II); lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 15 - 25 ℃; Inert atmosphere;

Reference yield: 53.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + tert-butyl 4-(piperazin-1-yl)benzoate (187669-28-9) + 4,4-dimethylcyclohexane-1-one (4255-62-3) → tert-butyl 4-{4-[(5,5-dimethyl-2-oxocyclohexyl)methyl]piperazin-1-yl}benzoate (1044598-92-6)

Guidance literature:

With hydrogenchloride; In tert-butyl alcohol; for 3h; Reflux;

DOI:10.1055/s-2008-1067129

upstream raw materials:

piperazine

tert-butyl 4-fluorobenzoate

Downstream raw materials:

tert-butyl 4-{4-[(5,5-dimethyl-2-oxocyclohexyl)methyl]piperazin-1-yl}benzoate

Refernces

• 1、 Wang, Guangjun,Zhang, Hushan,Zhou, Jing,Ha, Chengyong,Pei, Duanqing,Ding, Ke. "An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins". experimental part. p. 2398 - 2404. Retrieved 2009/04/07.