Technology Process of (R)-7-Chloro-4,6-dimethoxy-2-((R)-1-methyl-3-oxo-butyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
There total 1 articles about (R)-7-Chloro-4,6-dimethoxy-2-((R)-1-methyl-3-oxo-butyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 93 percent / pyridine
2: 94 percent / AlCl3 / chlorobenzene / 0.5 h / Heating
3: 73 percent / diisopropylazodicarboxylate, tributylphosphine
4: 78 percent / LHMDS / tetrahydrofuran / -78 °C
5: 95 percent / MsN3, Et3N
6: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
7: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
8: tetrahydrofuran / Ambient temperature
9: 100 percent / TFA
10: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
With
pyridine; hydrogenchloride; aluminium trichloride; rhodium(II) pivalate; 2,3-dimercapto-succinic acid; tributylphosphine; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; ozone; triethylamine; Methanesulfonyl azide; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; chlorobenzene; benzene;
DOI:10.1021/ja00022a075
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 49 percent / NaOMe / methanol / Ambient temperature
2: 95 percent / tetrahydrofuran / Ambient temperature
With
sodium methylate;
In
tetrahydrofuran; methanol;
DOI:10.1021/ja00022a075
