Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane

Base Information

Chemical Name:Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane
CAS No.:218152-62-6
Molecular Formula:C₂₁H₃₇IO₃Si
Molecular Weight:492.513
Hs Code.:

Synonyms:Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane

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Chemical Property of Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane

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Technology Process of Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane

There total 7 articles about Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 218152-59-1
(2S,3R,4S)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentan-1-ol

: 218152-62-6
Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane

Guidance literature:: With 1H-imidazole; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; benzene; for 0.5h;
DOI:10.1021/jo981370x

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 218152-62-6
Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 22 h / Ambient temperature

2: DIBAH / CH₂Cl₂ / 1 h / -78 °C

3: 1.) Et₃B, CF₃SO₂H, 2.) iPr₂NEt, 3.) aq. H₂O₂ / 1.) CH₂Cl₂, hexane, 0 deg C, 30 min, 2.) -78 deg C, 3 h; room temperature, 4 h, 3.) MeOH, room temperature, 1 h

4: 98 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / 0 °C

5: 72 percent / LiBH₄ / ethanol / 2 h / 0 °C

6: 100 percent / PPh₃, imidazole, iPr₂NEt, I₂ / diethyl ether; benzene / 0.5 h

With 1H-imidazole; lithium borohydride; triethyl borane; trifluoromethanesulfinic acid; dihydrogen peroxide; iodine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/jo981370x

Reference yield:

: 132969-60-9
(2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal

: 218152-62-6
Triethyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃B, CF₃SO₂H, 2.) iPr₂NEt, 3.) aq. H₂O₂ / 1.) CH₂Cl₂, hexane, 0 deg C, 30 min, 2.) -78 deg C, 3 h; room temperature, 4 h, 3.) MeOH, room temperature, 1 h

2: 98 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / 0 °C

3: 72 percent / LiBH₄ / ethanol / 2 h / 0 °C

4: 100 percent / PPh₃, imidazole, iPr₂NEt, I₂ / diethyl ether; benzene / 0.5 h

With 1H-imidazole; lithium borohydride; triethyl borane; trifluoromethanesulfinic acid; dihydrogen peroxide; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/jo981370x