O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate

Base Information

Chemical Name:O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate
CAS No.:501939-83-9
Molecular Formula:C₁₈H₁₉FIN₃O₅
Molecular Weight:503.269
Hs Code.:

Synonyms:O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate

There total 1 articles about O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501939-82-8
(5R)-methanesulfonic acid 3-(3-fluoro-4-iodophenyl)-2-oxo-oxazolidin-5-ylmethyl ester

: 264600-97-7
3-N-(t-butoxycarbonyl)amino-1,2-isoxazole

: 501939-83-9
O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate

Guidance literature:: 3-N-(t-butoxycarbonyl)amino-1,2-isoxazole; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃;

(5R)-methanesulfonic acid 3-(3-fluoro-4-iodophenyl)-2-oxo-oxazolidin-5-ylmethyl ester; In DMF (N,N-dimethyl-formamide); at 75 ℃; for 2h;

Reference yield:

: 501939-83-9
O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate

: 3-[3-fluoro-4-(1H-[1,2,3]triazol-4-yl)-phenyl]-5-(isoxazol-3-ylaminomethyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: TEA; P-(2-furyl)3; CuI / Pd₂dba3 / tetrahydrofuran

2.1: KOH / methanol

3.1: dioxane / 100 °C

3.2: trifluoroacetic acid

With potassium hydroxide; copper(l) iodide; trifuran-2-yl-phosphane; TEA; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1.1: Sonagashira coupling;
DOI:10.1016/j.bmcl.2006.10.063

Reference yield:

: 501939-83-9
O-tert-butyl (N-(5R)-3-{3-fluoro-4-iodophenyl}-1,3-oxazolidin-2-on-5-yl)methyl N-isoxazol-3-ylcarbamate

: [3-(4-ethynyl-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-isoxazol-3-yl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TEA; P-(2-furyl)3; CuI / Pd₂dba3 / tetrahydrofuran

2: KOH / methanol

With potassium hydroxide; copper(l) iodide; trifuran-2-yl-phosphane; TEA; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; 1: Sonagashira coupling;
DOI:10.1016/j.bmcl.2006.10.063