2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Base Information

Chemical Name:2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one
CAS No.:1234334-61-2
Molecular Formula:C₂₇H₃₂O₅
Molecular Weight:436.548
Hs Code.:

Synonyms:2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one

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Chemical Property of 2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one

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Technology Process of 2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one

There total 7 articles about 2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 289033-06-3
6-[(4-phenyl)-phenoxy]-1-hexanal

: 56070-87-2
2-methoxy-3,5,6-trimethyl-4H-pyran-4-one

: 1234334-61-2
2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Guidance literature:: 2-methoxy-3,5,6-trimethyl-4H-pyran-4-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

6-[(4-phenyl)-phenoxy]-1-hexanal; In tetrahydrofuran; at -78 ℃; for 3h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmc.2010.03.070

Reference yield:

: 6-(1,1′-biphenyl-4-yloxy)hexan-1-ol

: 1234334-61-2
2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

With oxalyl dichloride; dimethyl sulfoxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1016/j.bmc.2010.03.070

Reference yield:

: 92-69-3
4-Phenylphenol

: 1234334-61-2
2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 3 h / -78 °C / Inert atmosphere

With oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1016/j.bmc.2010.03.070