tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate
CAS No.:1323409-83-1
Molecular Formula:C₂₆H₂₉N₃O₆
Molecular Weight:479.533
Hs Code.:

Synonyms:tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate

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Chemical Property of tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate

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Technology Process of tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate

There total 12 articles about tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5-amino-4-(4-((4-(((tert-butoxycarbonyl)amino)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoic acid

: 1323409-83-1
tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate

Guidance literature:: With 1,1'-carbonyldiimidazole; In acetonitrile; at 100 ℃; for 16h;

Reference yield: 60.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzonitrile

: 1323409-83-1
tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate

Guidance literature:: With hydrogen; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 874-89-5
4-Cyanobenzyl alcohol

: 1323409-83-1
tert-butyl 4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 20 °C

2: dichloromethane / 5 h / 20 °C

3: 1,1'-carbonyldiimidazole / acetonitrile / 6 h / 95 °C

4: hydrogen / tetrahydrofuran; dichloromethane / 16 h / 20 °C

With hydrogen; triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetonitrile;