N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester

Base Information

Chemical Name:N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester
CAS No.:862711-26-0
Molecular Formula:C₂₀H₂₇NO₅
Molecular Weight:361.438
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester

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Chemical Property of N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester

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Technology Process of N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester

There total 6 articles about N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 862711-60-2
2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

: 862711-26-0
N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester

Guidance literature:: With sodium periodate; silica gel; In dichloromethane; for 0.333333h;
DOI:10.1021/jo050529k

Reference yield:

: 862711-13-5
N-tert-butoxycarbonyl-2-allyl-DL-pipecolic acid

: 862711-26-0
N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / 3 h / Heating

2: 99 percent / N-methylmorpholine oxide / OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol

3: 75 percent / NaIO₄/silica gel / CH₂Cl₂ / 0.33 h

With sodium periodate; silica gel; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1021/jo050529k

Reference yield:

: 862711-24-8
N-tert-butoxycarbonyl-2-allylpipecolic acid benzyl ester

: 862711-26-0
N-tert-butoxycarbonyl-2-(2-oxoethyl)pipecolic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / N-methylmorpholine oxide / OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol

2: 75 percent / NaIO₄/silica gel / CH₂Cl₂ / 0.33 h

With sodium periodate; silica gel; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo050529k