4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid

Base Information

• Chemical Name: 4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid
• CAS No.: 124769-88-6
• Molecular Formula: C₁₆H₁₉N₃O₄
• Molecular Weight: 317.345
• Mol file: 124769-88-6.mol

Synonyms:4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid

Chemical Property of 4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid

There total 6 articles about 4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride (124769-87-5) → 4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid (124769-88-6)

Guidance literature:

With sodium hydroxide; In methanol; water; at 60 ℃; for 1h;

DOI:10.1248/cpb.37.1780

Reference yield:

ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate (53554-29-3) → 4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid (124769-88-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / 2 h / 130 °C

2: 54 percent / POCl₃, N,N-diethylaniline / acetonitrile / 3 h / Heating

3: 68 percent / 3 h / Heating

4: 69 percent / NaOH / methanol; H₂O / 1 h / 60 °C

With sodium hydroxide; N,N-diethylaniline; trichlorophosphate; In methanol; water; acetonitrile;

DOI:10.1248/cpb.37.1780

Reference yield:

1-isobutoxy-2-nitrobenzene (56245-02-4) → 4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid (124769-88-6)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / 10percent Pd/C / methanol

2: 74 percent / 2 h / 130 °C

3: 54 percent / POCl₃, N,N-diethylaniline / acetonitrile / 3 h / Heating

4: 68 percent / 3 h / Heating

5: 69 percent / NaOH / methanol; H₂O / 1 h / 60 °C

With sodium hydroxide; hydrogen; N,N-diethylaniline; trichlorophosphate; palladium on activated charcoal; In methanol; water; acetonitrile;

DOI:10.1248/cpb.37.1780

upstream raw materials:

ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate

1-isobutoxy-2-nitrobenzene

2-(2-methylpropoxy)benzenamine