(E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate

Base Information

Chemical Name:(E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate
CAS No.:1318127-08-0
Molecular Formula:C₁₈H₁₇N₃O₂S
Molecular Weight:339.418
Hs Code.:

Synonyms:(E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate

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Technology Process of (E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate

There total 6 articles about (E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1318132-91-0
7-vinylthieno[3,2-d]pyrimidine-4-amine

: 859212-59-2
3-iodo-4-methyl-benzoic acid ethyl ester

: 1318127-08-0
(E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; trifuran-2-yl-phosphane; palladium diacetate; In N,N-dimethyl-formamide; at 120 ℃; for 18h;

Reference yield:

: 16234-10-9
3H-thieno[3,2-d]pyrimidin-4-one

: 1318127-08-0
(E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / acetic acid / 10 h / 120 °C / sealed reactor

2.1: trichlorophosphate / 3 h / 150 °C

3.1: ammonia / isopropyl alcohol / 12 h / 100 °C / sealed vessel

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 7 h / 120 °C / Inert atmosphere

4.2: 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; trifuran-2-yl-phosphane / N,N-dimethyl-formamide / 18 h / 120 °C

With ammonia; bromine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; palladium diacetate; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 31169-27-4
7-bromo-4-chlorothieno[3,2-d]pyrimidine

: 1318127-08-0
(E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / isopropyl alcohol / 12 h / 100 °C / sealed vessel

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 7 h / 120 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; trifuran-2-yl-phosphane / N,N-dimethyl-formamide / 18 h / 120 °C

With ammonia; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; palladium diacetate; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;