(2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

Base Information

Chemical Name:(2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate
CAS No.:1443041-74-4
Molecular Formula:C₄₂H₃₄ClNO₆
Molecular Weight:684.188
Hs Code.:

Synonyms:(2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

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Chemical Property of (2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

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Technology Process of (2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

There total 2 articles about (2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 122750-25-8
6-chloro-N-methylisatin

: 1443041-93-7
dibenzhydryl 2-vinylcyclopropane-1,1-dicarboxylate

: 1443041-74-4
(2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (4R,5R)-2-((S)-1-(2-(dibutylphosphino)naphthalen-1-yl)naphthalen-2-yl)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazole; lithium chloride; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere; Schlenk technique;
DOI:10.1021/om400473p

Reference yield:

: 116021-77-3
C₂₉H₂₄O₄

: 1443041-74-4
(2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere; Schlenk technique

2: (4R,5R)-2-((S)-1-(2-(dibutylphosphino)naphthalen-1-yl)naphthalen-2-yl)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium chloride / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Schlenk technique

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (4R,5R)-2-((S)-1-(2-(dibutylphosphino)naphthalen-1-yl)naphthalen-2-yl)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazole; caesium carbonate; lithium chloride; In tetrahydrofuran;
DOI:10.1021/om400473p

Reference yield: 91.0%

: 1443041-74-4
(2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

: 1443041-90-4
(2S,5S)-dibenzhydryl-6'-chloro-5-formyl-1'-methyl-2'-oxo-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate

Guidance literature:: (2S,5S)-dibenzhydryl 6'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate; With ozone; In methanol; dichloromethane; at -78 ℃; Inert atmosphere; Schlenk technique;

With acetic acid; zinc; In methanol; dichloromethane; at -78 - 20 ℃; for 21h; Inert atmosphere; Schlenk technique;
DOI:10.1021/om400473p