Boc-D-FMK

Base Information

• Chemical Name: Boc-D-FMK
• CAS No.: 187389-53-3
• Molecular Formula: C₁₁H₁₈FNO₅
• Molecular Weight: 263.266
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID50940205
• Mol file: 187389-53-3.mol

Synonyms:Boc-D-FMK

Chemical Property of Boc-D-FMK

Chemical Property:

• Boiling Point: 383.5±37.0 °C(Predicted)
• PKA: 10.12±0.46(Predicted)
• PSA: 81.70000
• Density: 1.150±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.37230
• Storage Temp.: −20°C
• Solubility.: Soluble in dry DMSO or DMF at approximately 20mM. Store stock so
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 263.11690084
• Heavy Atom Count: 18
• Complexity: 324

Purity/Quality:

97% ^*data from raw suppliers

Boc-D-FMK ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF
• Uses: N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications. Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Technology Process of Boc-D-FMK

There total 1 articles about Boc-D-FMK which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H19N3O5 + monobenzyl-fluoromalonate magnesium enolate → Boc-D-FMK (187389-53-3,634911-80-1)

Guidance literature:

C₁₃H₁₉N₃O₅; monobenzyl-fluoromalonate magnesium enolate; In tetrahydrofuran; at -20 - 20 ℃; for 4.25h;

With hydrogen; palladium on activated charcoal; In ethyl acetate; Further stages.;

DOI:10.1039/b711531h

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