(R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid

Base Information

• Chemical Name: (R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid
• CAS No.: 346722-44-9
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• Mol file: 346722-44-9.mol

Synonyms:(R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid

Chemical Property of (R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid

There total 1 articles about (R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(S)-2-amino-4-methylpentan-1-ol (7533-40-6,14438-11-0) + Benzoylacrylic acid (17812-07-6) → (R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid (346722-44-9)

Guidance literature:

In dichloromethane; at 25 - 30 ℃; for 168h; crystallization-induced dynamic resolution;

DOI:10.1016/S0040-4039(01)00221-0

Reference yield:

(R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid (346722-44-9) → (R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-phenyl-butyric acid (346722-52-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In hydrogenchloride; for 24h;

DOI:10.1016/S0040-4039(01)00221-0

Reference yield:

(R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-oxo-4-phenyl-butyric acid (346722-44-9) → D-homophenylalanine (82795-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / aq. HCl / 24 h

2: Pb(OAc)4 / methanol

With lead(IV) acetate; hydrogen; palladium on activated charcoal; In hydrogenchloride; methanol;

DOI:10.1016/S0040-4039(01)00221-0

upstream raw materials:

(S)-2-amino-4-methylpentan-1-ol

Benzoylacrylic acid

Downstream raw materials:

(R)-2-((S)-1-Hydroxymethyl-3-methyl-butylamino)-4-phenyl-butyric acid

D-homophenylalanine