(1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

Base Information

Chemical Name:(1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester
CAS No.:208037-92-7
Molecular Formula:C₁₆H₂₀ClNO₂Se
Molecular Weight:372.753
Hs Code.:

Synonyms:(1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

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Chemical Property of (1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

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Technology Process of (1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

There total 4 articles about (1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74242-55-0
anhydroecgonine hydrochloride

: 208037-92-7
(1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / H₂ / Pd/C / methanol / 6.5 h / 3102.9 Torr / Ambient temperature

2: 1.) (COCl)2, DMF, 2.) N-hydroxy-2-thiopyridone / 1.) CH₂ClCH₂Cl, room temperature, 12 h, 2.) CH₂ClCH₂Cl, room temperature, 1.5 h, 3.) CH₂Cl₂, irradiation, 0 deg C, 2 h

3: toluene / 24 h / Heating

With 1-hydroxy-2(1H)-pyridinethione; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; toluene;
DOI:10.1021/jo980153t

Reference yield:

: 53-21-4
(-)-cocaine hydrochloride

: 208037-92-7
(1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / conc. HCl / 24 h / Heating

2: 93 percent / H₂ / Pd/C / methanol / 6.5 h / 3102.9 Torr / Ambient temperature

3: 1.) (COCl)2, DMF, 2.) N-hydroxy-2-thiopyridone / 1.) CH₂ClCH₂Cl, room temperature, 12 h, 2.) CH₂ClCH₂Cl, room temperature, 1.5 h, 3.) CH₂Cl₂, irradiation, 0 deg C, 2 h

4: toluene / 24 h / Heating

With hydrogenchloride; 1-hydroxy-2(1H)-pyridinethione; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; toluene;
DOI:10.1021/jo980153t

Reference yield:

: (1R,5R)-8-Methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid; hydrochloride

: 208037-92-7
(1R,2S,5S)-2-Phenylselanyl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (COCl)2, DMF, 2.) N-hydroxy-2-thiopyridone / 1.) CH₂ClCH₂Cl, room temperature, 12 h, 2.) CH₂ClCH₂Cl, room temperature, 1.5 h, 3.) CH₂Cl₂, irradiation, 0 deg C, 2 h

2: toluene / 24 h / Heating

With 1-hydroxy-2(1H)-pyridinethione; oxalyl dichloride; N,N-dimethyl-formamide; In toluene;
DOI:10.1021/jo980153t