N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Base Information

Chemical Name:N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide
CAS No.:1380647-08-4
Molecular Formula:C₂₅H₂₆FN₅O₅
Molecular Weight:495.51
Hs Code.:

Synonyms:N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

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Chemical Property of N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

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Technology Process of N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

There total 6 articles about N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: 1380647-40-4
N'-(3-(benzyloxy)-2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

: 1380647-08-4
N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 16h;

Reference yield:

: 1188429-06-2
ethyl 10-(((benzyloxy)carbonyl)amino)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a] azepine-2-carboxylate

: 1380647-08-4
N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: water; lithium hydroxide monohydrate / ethanol / 16 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

4: triethylamine / dichloromethane / 16 h / 20 °C

5: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 2 h

6: dmap; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

8: Burgess Reagent / tetrahydrofuran / 5 h / Reflux

9: trifluoroacetic acid / dichloromethane / 16 h / 40 °C

With hydrogenchloride; dmap; oxalyl dichloride; Burgess Reagent; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1380647-28-8
3-(benzyloxy)-10-(((benzyloxy)carbonyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid

: 1380647-08-4
N'-(2-(5-(4-fluorobenzyl)-1,3-oxazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

2: triethylamine / dichloromethane / 16 h / 20 °C

3: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 2 h

4: dmap; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

6: Burgess Reagent / tetrahydrofuran / 5 h / Reflux

7: trifluoroacetic acid / dichloromethane / 16 h / 40 °C

With hydrogenchloride; dmap; oxalyl dichloride; Burgess Reagent; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;