5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester

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Chemical Name:5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester
CAS No.:221077-58-3
Molecular Formula:C₃₂H₄₃N₃O₉
Molecular Weight:613.708
Hs Code.:

Synonyms:5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester

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Chemical Property of 5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester

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Technology Process of 5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester

There total 7 articles about 5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 221077-57-2
methyl 2-[2-(benzyloxy)-2-oxoethoxy]-5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]benzoate

: 221077-58-3
5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester

Guidance literature:: With hydrogen; 10percent Pd/C; In methanol; for 2h; atmospheric pressure;
DOI:10.1021/jm011100y

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 221077-58-3
5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 0.85 g / 1-hydroxybenzotriazole; EDC / CH₂Cl₂ / 20 °C

2: 97 percent / H₂ / 10percent Pd/C / methanol / 2 h / atmospheric pressure

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm011100y

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 221077-58-3
5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / Et₃N; 1,1'-bis(diphenylphosphino)ferrocene / palladium(II) acetate / dimethylformamide / 16 h / 70 °C

2: 84 percent / K₂CO₃ / acetone / 50 °C

3: TFA / CH₂Cl₂ / 4 h / 0 - 20 °C

4: 0.85 g / 1-hydroxybenzotriazole; EDC / CH₂Cl₂ / 20 °C

5: 97 percent / H₂ / 10percent Pd/C / methanol / 2 h / atmospheric pressure

With 1,1'-bis-(diphenylphosphino)ferrocene; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium diacetate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm011100y