4-BOC-AMINOMETHYLPHENETHYLAMINE

Base Information

• Chemical Name: 4-BOC-AMINOMETHYLPHENETHYLAMINE
• CAS No.: 187283-19-8
• Molecular Formula: C14H22 N2 O2
• Molecular Weight: 250.341
• Hs Code.: 2924299090
• Mol file: 187283-19-8.mol

Synonyms:[4-(2-AMINO-ETHYL)-BENZYL]-CARBAMIC ACID TERT-BUTYL ESTER;4-BOC-AMINOMETHYLPHENETHYLAMINE

Chemical Property of 4-BOC-AMINOMETHYLPHENETHYLAMINE

Chemical Property:

• Boiling Point: 396.8±30.0 °C(Predicted)
• PKA: 12.30±0.46(Predicted)
• PSA: 64.35000
• Density: 1.055±0.06 g/cm3(Predicted)
• LogP: 3.30370

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Boc-aminomethylphenethylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BOC-AMINOMETHYLPHENETHYLAMINE

There total 5 articles about 4-BOC-AMINOMETHYLPHENETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl N-[[4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]phenyl]methyl]carbamate → tert-butyl N-[[4-(2-aminoethyl)phenyl]methyl]carbamate (187283-19-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

2-(2-(4-bromophenyl)ethyl)isoindolin-1,3-dione (124499-18-9) → tert-butyl N-[[4-(2-aminoethyl)phenyl]methyl]carbamate (187283-19-8)

Guidance literature:

Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

2: hydrogenchloride; hydrogen / methanol; water; tetrahydrofuran / 16 h / 25 °C / 2327.23 Torr

3: sodium hydrogencarbonate / methanol; water / 16 h / 20 °C / Inert atmosphere

4: hydrazine hydrate / ethanol / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; sodium hydrogencarbonate; hydrazine hydrate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzonitrile (308846-03-9) → tert-butyl N-[[4-(2-aminoethyl)phenyl]methyl]carbamate (187283-19-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; hydrogen / methanol; water; tetrahydrofuran / 16 h / 25 °C / 2327.23 Torr

2: sodium hydrogencarbonate / methanol; water / 16 h / 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; hydrazine hydrate; In tetrahydrofuran; methanol; ethanol; water;

upstream raw materials:

2-(2-(4-bromophenyl)ethyl)isoindolin-1,3-dione

4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzonitrile

4-Bromophenethylamine

Downstream raw materials:

4-[2-(aminocarbonylamino)ethyl]-N-[(1,1-dimethylethoxy)carbonyl]benzenemethanamine

Refernces