methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester

Base Information

• Chemical Name: methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester
• CAS No.: 926907-24-6
• Molecular Formula: C₂₃H₂₆O₁₀S
• Molecular Weight: 494.519
• Mol file: 926907-24-6.mol

Synonyms:methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester

Chemical Property of methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester

There total 11 articles about methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-(2-nitro-phenylselanylmethyl)-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester → methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester (926907-24-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 40 ℃;

DOI:10.1016/j.tetlet.2006.11.170

Reference yield:

3-methoxy-5-(2-methyl-[1,3]dioxolan-2-yl)-[1,2]benzoquinone (926906-98-1) → methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester (926907-24-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / tetrahydrofuran / 3 h / 20 °C

2: 60 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: 100 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

4: 57 percent / n-Bu₃P / tetrahydrofuran / 20 °C

5: 94 percent / m-CPBA / CH₂Cl₂ / 40 °C

With tributylphosphine; tetrabutyl ammonium fluoride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2006.11.170

Reference yield:

2,6-dimethoxy-4-(2-methyl-[1,3]dioxolan-2-yl)-phenol (926907-08-6) → methanesulfonic acid 2,6-dimethoxy-4-[5-methoxy-7-(2-methyl-[1,3]dioxolan-2-yl)-3-methylene-2,3-dihydro-benzo[1,4]dioxin-2-yl]-phenyl ester (926907-24-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 82 percent / IBX / dimethylsulfoxide / 0.5 h / 20 °C

2: 83 percent / tetrahydrofuran / 3 h / 20 °C

3: 60 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

4: 100 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

5: 57 percent / n-Bu₃P / tetrahydrofuran / 20 °C

6: 94 percent / m-CPBA / CH₂Cl₂ / 40 °C

With tributylphosphine; tetrabutyl ammonium fluoride; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2006.11.170

upstream raw materials:

3-methoxy-5-(2-methyl-[1,3]dioxolan-2-yl)-[1,2]benzoquinone

2,6-dimethoxy-4-(2-methyl-[1,3]dioxolan-2-yl)-phenol

1-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-ethanol

methyl 4-O-tert-butyldimethylsilyl-3,5-dimethoxybenzoate

Downstream raw materials:

methanesulfonic acid 4-(7-acetyl-3-hydroxy-5-methoxy-3-methyl-2,3-dihydro-benzo[1,4]dioxin-2-yl)-2,6-dimethoxy-phenyl ester