β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose

Base Information

Chemical Name:β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose
CAS No.:1356140-71-0
Molecular Formula:C₄₀H₃₆N₄O₇
Molecular Weight:684.748
Hs Code.:

Synonyms:β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose

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Chemical Property of β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose

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Technology Process of β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose

There total 3 articles about β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1356140-70-9
10-(β-D-2-deoxyribos-1-yl)-3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1356140-71-0
β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose

Guidance literature:: With pyridine; at 20 ℃; for 6h;
DOI:10.1039/c1ob06411h

Reference yield:

: 614-96-0
5-methyl-1H-indole

: 1356140-71-0
β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / acetonitrile / 20 °C

2.1: Triisopropyl borate; lithium diisopropyl amide / tetrahydrofuran / 3 h / 0 °C

2.2: pH 6 / aq. phosphate buffer

3.1: palladium diacetate; sodium carbonate; trisodium triphenylphosphine‐3,3′,3″‐trisulfonate / water; acetonitrile / 15 h / 45 °C / Inert atmosphere

4.1: pyridine / 6 h / 20 °C

With pyridine; dmap; Triisopropyl borate; palladium diacetate; sodium carbonate; trisodium triphenylphosphine‐3,3′,3″‐trisulfonate; lithium diisopropyl amide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1039/c1ob06411h

Reference yield:

: 475102-14-8
{1-[(tert-butoxy)carbonyl]-5-methyl-1H-indol-2-yl}boronic acid

: 1356140-71-0
β-D-1-(3-methyl-pyrimido[4,5-d]pyrimido[1,6-a]indol-10-yl)-5-O-(4,4'-dimethoxytrityl)-2-deoxyribose

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; sodium carbonate; trisodium triphenylphosphine‐3,3′,3″‐trisulfonate / water; acetonitrile / 15 h / 45 °C / Inert atmosphere

2: pyridine / 6 h / 20 °C

With pyridine; palladium diacetate; sodium carbonate; trisodium triphenylphosphine‐3,3′,3″‐trisulfonate; In water; acetonitrile;
DOI:10.1039/c1ob06411h