2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

Base Information

Chemical Name:2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate
CAS No.:756499-67-9
Molecular Formula:C₁₆H₁₄F₃NO₄
Molecular Weight:341.287
Hs Code.:

Synonyms:2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

Suppliers and Price of 2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

There total 10 articles about 2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 756499-57-7
ethyl 3-(4-chlorophenylsulfanyl)-2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridine-3-yl)propionate

: 756499-67-9
2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 95 percent / Raney nickel / acetone; ethanol; H₂O / 12 h / 25 °C

2.1: 93 percent / TFA / toluene / 12 h / 110 °C

3.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: 324 mg / Et₃N / CH₂Cl₂; H₂O / 0.33 h / 25 °C

5.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

5.2: tetrahydrofuran / -78 - 0 °C

6.1: 203 mg / AcOH / CH₂Cl₂ / 0.33 h / 25 °C

7.1: 40 percent / LAH / tetrahydrofuran / 20 °C

8.1: CH₂Cl₂ / 24 h / 25 °C

With lithium aluminium tetrahydride; n-butyllithium; acetic acid; triethylamine; trifluoroacetic acid; nickel; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetone; toluene; 5.1: Claisen condensation;
DOI:10.1021/ol049130t

Reference yield:

: 102249-52-5
4-hydroxy-5-phenylpyridin-2(1H)-one

: 756499-67-9
2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 40 percent / HCOOH; Et₃N / 5 h / 140 - 150 °C / sealed tube

2.1: 98 percent / conc. H₂SO₄ / ethanol / 60 °C

3.1: 93 percent / TFA / toluene / 12 h / 110 °C

4.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5.1: 324 mg / Et₃N / CH₂Cl₂; H₂O / 0.33 h / 25 °C

6.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

6.2: tetrahydrofuran / -78 - 0 °C

7.1: 203 mg / AcOH / CH₂Cl₂ / 0.33 h / 25 °C

8.1: 40 percent / LAH / tetrahydrofuran / 20 °C

9.1: CH₂Cl₂ / 24 h / 25 °C

With lithium aluminium tetrahydride; n-butyllithium; formic acid; sulfuric acid; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene; 1.1: Knoevenagel condensation / 6.1: Claisen condensation;
DOI:10.1021/ol049130t

Reference yield:

: 756499-69-1
2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridine-3-yl)propionic acid

: 756499-67-9
2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 98 percent / conc. H₂SO₄ / ethanol / 60 °C

2.1: 93 percent / TFA / toluene / 12 h / 110 °C

3.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: 324 mg / Et₃N / CH₂Cl₂; H₂O / 0.33 h / 25 °C

5.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

5.2: tetrahydrofuran / -78 - 0 °C

6.1: 203 mg / AcOH / CH₂Cl₂ / 0.33 h / 25 °C

7.1: 40 percent / LAH / tetrahydrofuran / 20 °C

8.1: CH₂Cl₂ / 24 h / 25 °C

With lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene; 5.1: Claisen condensation;
DOI:10.1021/ol049130t