(1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine

Base Information

Chemical Name:(1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine
CAS No.:945534-11-2
Molecular Formula:C₃₉H₃₇N₅O₅
Molecular Weight:655.753
Hs Code.:

Synonyms:(1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine

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Chemical Property of (1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine

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Technology Process of (1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine

There total 6 articles about (1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 945534-09-8
(1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-6-hydroxymethyl)-β-oxepanyl]-N⁶-benzoyladenine

: 14470-28-1
mono-4-methoxytrityl chloride

: 945534-11-2
(1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine

Guidance literature:: With pyridine; at 22 ℃; for 4h;
DOI:10.1021/ja071336c

Reference yield: 50.0%

: 945534-11-2
(1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine

Guidance literature:

Reference yield:

: 191593-14-3
4,6-O-di(tert-butyl)silanediyl-D-glucal

: 945534-11-2
(1R)-1-[(2,3,4-trideoxy-(5S,6R)-5-hydroxy-7-[4-(methoxyphenyl)diphenyl])-β-oxepanyl]-N6-benzoyladenine

Guidance literature:: Multi-step reaction with 6 steps

1: ZnEt₂ / hexane

2: pyridine

3: 30 percent / TMSOTf / acetonitrile / 90 °C

4: 61 percent / TBAF / tetrahydrofuran / 1 h / 0 °C

5: 99 percent / H₂ / Pd/C / methanol / 4 h / 22 °C / 760.05 Torr

6: 50 percent / pyridine / 4 h / 22 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; diethylzinc; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; acetonitrile; 1: Simmons-Smiths reaction / 3: Vorbrueggen glycosylation;
DOI:10.1021/ja071336c