3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Base Information

• Chemical Name: 3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂
• CAS No.: 97119-39-6
• Molecular Formula: C₄₁H₅₀N₄O₁₄S₅
• Molecular Weight: 983.196

Synonyms:3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Chemical Property of 3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Chemical Property:

Purity/Quality:

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Technology Process of 3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

There total 6 articles about 3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-38-5) → 3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-39-6)

Guidance literature:

With ammonia; In methanol; for 0.166667h;

DOI:10.1002/jlac.198519850511

Reference yield:

Sisamin (47086-84-0,68297-05-2) → 3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-39-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / K₂CO₃ / H₂O; dioxane / 1) from 0 deg C to room temp., 2) 2 h, 20 deg C

2: 84 percent / pyridine; CH₂Cl₂ / 3 h / Ambient temperature

3: 32 percent / NaH / dimethylformamide / 0.5 h / 0 °C

4: 76 percent / dimethylformamide / 0.17 h / 60 °C

5: 90 percent / NH₃ / methanol / 0.17 h

With ammonia; sodium hydride; potassium carbonate; In 1,4-dioxane; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/jlac.198519850511

Reference yield:

1,2',3,6'-Tetrakis-N-(p-tolylsulfonyl)sisamin (97119-33-0) → 3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-39-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / pyridine; CH₂Cl₂ / 3 h / Ambient temperature

2: 32 percent / NaH / dimethylformamide / 0.5 h / 0 °C

3: 76 percent / dimethylformamide / 0.17 h / 60 °C

4: 90 percent / NH₃ / methanol / 0.17 h

With ammonia; sodium hydride; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jlac.198519850511

upstream raw materials:

3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Sisamin

1,2',3,6'-Tetrakis-N-(p-tolylsulfonyl)sisamin

1-Desamino-6-desoxy-5-O-(methylsulfonyl)-2',3,6'-tris-N-(p-tolylsulfonyl)-1,6-<(p-tolylsulfonyl)epimino>sisamin

Downstream raw materials:

3-O,4-N-Didesmethylfortimicin KG₂

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