(E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one

Base Information

Chemical Name:(E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one
CAS No.:1341192-99-1
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:(E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one

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Chemical Property of (E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one

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Technology Process of (E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one

There total 4 articles about (E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1-benzyl-2,3-dihydro-2-(4-methoxyphenyl)pyridin-4(1H)-one

: 1341192-99-1
(E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: With copper diacetate; palladium diacetate; potassium trifluoroacetate; In N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere; Sealed vessel;
DOI:10.1021/ol202677g

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 1341192-99-1
(E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 2.5 h / 0 - 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: copper diacetate; palladium diacetate; potassium trifluoroacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere; Sealed vessel

With trimethylsilyl trifluoromethanesulfonate; copper diacetate; palladium diacetate; potassium trifluoroacetate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Fujiwara-Moritani reaction;
DOI:10.1021/ol202677g

Reference yield:

: 72359-37-6
1-benzylpyridin-4(1H)-one

: 1341192-99-1
(E)-1-benzyl-5-(2-(methoxycarbonyl)vinyl)-2-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: copper diacetate; palladium diacetate; potassium trifluoroacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere; Sealed vessel

With trimethylsilyl trifluoromethanesulfonate; copper diacetate; palladium diacetate; potassium trifluoroacetate; In dichloromethane; N,N-dimethyl-formamide; 2.1: Fujiwara-Moritani reaction;
DOI:10.1021/ol202677g