(S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:207915-36-4
Molecular Formula:C₂₀H₂₉NO₄
Molecular Weight:347.455
Hs Code.:

Synonyms:(S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 16 articles about (S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 207915-35-3
(S)-2-(3-Benzyl-4-triisopropylsilanyloxy-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 207915-36-4
(S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 1h;
DOI:10.1039/a800756j

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 207915-36-4
(S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: CH₂Cl₂

3: 73 percent / LiAlH₄ / diethyl ether

4: 1.) BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C to r.t., 3 h

5: 1.) BH₃*DMS, 2.) NaOH, H₂O₂, H₂O / 1.) THF, 40 deg C, 18 h, 2.) THF, 3 h

6: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 25 °C

7: 80 percent / TBAF / tetrahydrofuran / 1 h / 25 °C

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; water; dihydrogen peroxide; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/a800756j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 207915-36-4
(S)-2-(3-Hydroxymethyl-4-phenyl-butyryl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / Et₃N / tetrahydrofuran / 0 °C

2: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C to r.t., 3 h

4: 1.) BH₃*DMS, 2.) NaOH, H₂O₂, H₂O / 1.) THF, 40 deg C, 18 h, 2.) THF, 3 h

5: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 25 °C

6: 80 percent / TBAF / tetrahydrofuran / 1 h / 25 °C

With sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; water; dihydrogen peroxide; Dess-Martin periodane; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/a800756j