(S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester

Base Information

Chemical Name:(S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester
CAS No.:121353-05-7
Molecular Formula:C₂₈H₄₂O₃SSi
Molecular Weight:486.791
Hs Code.:

Synonyms:(S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester

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Technology Process of (S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester

There total 4 articles about (S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 121353-05-7
(S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylamine, imidazole / CH₂Cl₂ / 40 h / Ambient temperature

2: 1.) ozone, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 2.) 30 min

3: 1.) diisopropylethylamine, (R,R)-2,5-trans-dimethylborolanyl trifluoromethanesulfonate / 1.) pentane, a) -78 deg C, 30 min, b) 0 deg C, 1 h, 2.) -78 deg C, 1 h

With 1H-imidazole; dimethylsulfide; (R,R)-2,5-trans-dimethylborolanyl trifluoromethanesulfonate; ozone; diisopropylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00273a009

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 121353-05-7
(R)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylamine, imidazole / CH₂Cl₂ / 40 h / Ambient temperature

2: 1.) ozone, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 2.) 30 min

3: 1.) diisopropylethylamine, (R,R)-2,5-trans-dimethylborolanyl trifluoromethanesulfonate / 1.) pentane, a) -78 deg C, 30 min, b) 0 deg C, 1 h, 2.) -78 deg C, 1 h

With 1H-imidazole; dimethylsulfide; (R,R)-2,5-trans-dimethylborolanyl trifluoromethanesulfonate; ozone; diisopropylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00273a009

Reference yield:

: 121353-04-6
(Z)-tert-butyl(hex-3-en-1-yloxy)diphenylsilane

: 121353-05-7
(R)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ozone, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 2.) 30 min

2: 1.) diisopropylethylamine, (R,R)-2,5-trans-dimethylborolanyl trifluoromethanesulfonate / 1.) pentane, a) -78 deg C, 30 min, b) 0 deg C, 1 h, 2.) -78 deg C, 1 h

With dimethylsulfide; (R,R)-2,5-trans-dimethylborolanyl trifluoromethanesulfonate; ozone; N-ethyl-N,N-diisopropylamine;
DOI:10.1021/jo00273a009