(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile

Base Information

Chemical Name:(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile
CAS No.:856688-66-9
Molecular Formula:C₃₂H₄₅N₃O₃Si
Molecular Weight:547.813
Hs Code.:

Synonyms:(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile

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Chemical Property of (1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile

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Technology Process of (1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile

There total 10 articles about (1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 856688-64-7
1-{(2S)-2-[(S)-{[tert-butyl(dimethyl)silyl]oxy}(3,5-dimethoxy-4-methylphenyl)methyl]-5-phenylpentyl}-4-(chloromethyl)-1H-pyrazole

: 143-33-9,25596-52-5
sodium cyanide

: 856688-66-9
(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 0.333333h;

Reference yield:

: 773837-37-9
sodium cyanide

: 856688-62-5
(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)methanol

: 856688-66-9
(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile

Guidance literature:: (1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)methanol; With methanesulfonyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; at 20 ℃; for 1h;

sodium cyanide; In dimethyl sulfoxide; at 20 ℃; for 0.333333h;
DOI:10.1021/acsmedchemlett.7b00383

Reference yield:

: 1011-27-4
3,5-dimethoxy-4-methylbenzaldehyde

: 856688-66-9
(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acetonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; chloro-trimethyl-silane; magnesium chloride / ethyl acetate / 20 °C

1.2: 0.08 h

2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C

3.1: lithium borohydride / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

5.1: sodium iodide / acetone / 3 h / 90 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 20 °C

8.1: triethylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 1 h / 20 °C

8.2: 0.33 h / 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; lithium borohydride; chloro-trimethyl-silane; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide; lithium chloride; magnesium chloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/acsmedchemlett.7b00383