Chemical Property of N'-methoxy-4-[5-[4-[(E)-N'-methoxycarbamimidoyl]phenyl]-2-furyl]benzamidine
Chemical Property:
- Melting Point:192.5-193 °C
- Boiling Point:457.7±55.0 °C(Predicted)
- PKA:6.01±0.50(Predicted)
- PSA：108.36000
- Density:1.25 g/cm3
- LogP:4.54760
- Storage Temp.:-20°C Freezer, Under inert atmosphere
- Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
- XLogP3:3.2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:6
- Exact Mass:364.15354051
- Heavy Atom Count:27
- Complexity:477
- Purity/Quality:
-
97% *data from raw suppliers
Pafuramidine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CON=C(C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=C(C=C3)C(=NOC)N)N
- Isomeric SMILES:CO/N=C(/N)\C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=C(C=C3)/C(=N\OC)/N
- Recent ClinicalTrials:Trial of DB289 for the Treatment of Stage I African Trypanosomiasis
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Uses
Treatment of malaria, African
sleeping sickness, and pneumocystis pneumonia. Pafuramidine is a prodrug of Furamidine (F863600, 2HCl); a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines.
