(S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone

Base Information

Chemical Name:(S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone
CAS No.:293321-26-3
Molecular Formula:C₂₁H₂₉NO₆Si
Molecular Weight:419.55
Hs Code.:

Synonyms:(S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone

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Chemical Property of (S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone

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Technology Process of (S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone

There total 4 articles about (S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 293321-25-2
(S)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-methoxycarbonyl-3-(phenylselanyl)-2-piperidone

: 293321-26-3
(S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone

Guidance literature:: With ozone; In dichloromethane; at -78 - 25 ℃;
DOI:10.1016/S0040-4020(00)00317-3

Reference yield:

: 138565-91-0
(5S)-methyl 5-(tert-butyldimethylsilanyloxy)-2-oxopiperidine-1-carboxylate

: 293321-26-3
(S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 3 steps

1: LHMDS / tetrahydrofuran / 0.33 h / -78 °C

2: 0.67 g / LHMDS / tetrahydrofuran / -78 - 25 °C

3: 78 percent / O₃ / CH₂Cl₂ / -78 - 25 °C

With ozone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Elimination;
DOI:10.1016/S0040-4020(00)00317-3

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 293321-26-3
(S)-(+)-3-(benzyloxycarbonyl)-5-(tert-butyldimethylsilyloxy)-1-(methoxycarbonyl)-5,6-dihydro-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 3 steps

1: LHMDS / tetrahydrofuran / 0.33 h / -78 °C

2: 0.67 g / LHMDS / tetrahydrofuran / -78 - 25 °C

3: 78 percent / O₃ / CH₂Cl₂ / -78 - 25 °C

With ozone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Elimination;
DOI:10.1016/S0040-4020(00)00317-3