ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate

Base Information

Chemical Name:ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate
CAS No.:141887-35-6
Molecular Formula:C₂₅H₂₇N₇O₂
Molecular Weight:457.535
Hs Code.:

Synonyms:ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate

Suppliers and Price of ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate

There total 7 articles about ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157360-97-9
ethyl 6-methyl-2-{N-propyl-N-[(2'-[N-triphenylmethyl-1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate

: 141887-35-6
ethyl 6-methyl-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrazine-3-carboxylate

Guidance literature:: With hydrogenchloride; In ethanol;

Reference yield:

: 151322-64-4
ethyl 6-methyl-2-biphenyl-4-yl>methyl>amino>pyrazine-3-carboxylate

: 141887-35-6
5-Methyl-3-{propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-pyrazine-2-carboxylic acid ethyl ester

Guidance literature:: With formic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00070a012

Reference yield:

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 141887-35-6
5-Methyl-3-{propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-pyrazine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / Ambient temperature

2: Et₃N / dimethylformamide; toluene / 18 h / 45 °C

3: 88percent aq. HCOOH / CH₂Cl₂ / 2 h / Ambient temperature

With formic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00070a012