2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide

Base Information

• Chemical Name: 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide
• CAS No.: 906666-21-5
• Molecular Formula: C₃₂H₃₂N₂O₅
• Molecular Weight: 524.616
• Mol file: 906666-21-5.mol

Synonyms:2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide

Chemical Property of 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide

There total 2 articles about 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.7%

(S)-2-Acetylamino-3-trityloxy-propionic acid (906666-20-4) + dopamine hydrochloride (62-31-7) → 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide (906666-21-5)

Guidance literature:

(S)-2-Acetylamino-3-trityloxy-propionic acid; With (2-chloropropyl)dimethylamine hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 2h;

dopamine hydrochloride; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/ol061098a

Reference yield:

N-acetyl-L-serine (16354-58-8) → 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide (906666-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 65.3 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

2.1: 1-hydroxybenzotriazole; 2-dimethylaminoisopropyl chloride hydrochloride / dimethylformamide / 2 h

2.2: 73.7 percent / potassium carbonate / dimethylformamide / 12 h / 20 °C

With (2-chloropropyl)dimethylamine hydrochloride; benzotriazol-1-ol; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol061098a

Reference yield: 63.2%

2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-trityloxy-propionamide (906666-21-5) → N-(3,4-dihydroxyphenethyl)-2-acetamido-3-hydroxypropanamide

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ol061098a

upstream raw materials:

(S)-2-Acetylamino-3-trityloxy-propionic acid

dopamine hydrochloride

N-acetyl-L-serine