N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

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Chemical Name:N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide
CAS No.:172280-78-3
Molecular Formula:C₄₀H₄₄F₃N₃O₈
Molecular Weight:751.8
Hs Code.:

N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

Synonyms:N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

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Chemical Property of N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

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Technology Process of N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

There total 10 articles about N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 172280-76-1
N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

: 172280-78-3
N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)78243-8

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 172280-78-3
N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dimethylsulfoxide

2: 65 percent / NaH / dimethylsulfoxide

3: 1.) BH₃, dimethylsulfide; 2.) sodium perborate

5: NaN₃

6: 1,3-propanedithiol / reduction

7: triethylamine

8: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran

With 1.3-propanedithiol; sodium azide; sodium perborate; dimethylsulfide; borane; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)78243-8

Reference yield:

: 139887-99-3
3'-O-(tert-butyldimethylsilyl)-4'-(hydroxymethyl)-thymidine

: 172280-78-3
N-{(E)-7-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-hept-6-enyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: oxalylchloride, triethylamine / dimethylsulfoxide

2: triethylamine / dimethylsulfoxide

3: 65 percent / NaH / dimethylsulfoxide

4: 1.) BH₃, dimethylsulfide; 2.) sodium perborate

6: NaN₃

7: 1,3-propanedithiol / reduction

8: triethylamine

9: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran

With 1.3-propanedithiol; sodium azide; sodium perborate; dimethylsulfide; Chloro-oxo-acetic acid; borane; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)78243-8