(2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

Base Information

Chemical Name:(2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran
CAS No.:156414-47-0
Molecular Formula:C₃₁H₄₄O₇S
Molecular Weight:560.752
Hs Code.:

Synonyms:(2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

Suppliers and Price of (2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

There total 26 articles about (2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 156414-55-0
(2R,3S,5R,6R)-2-Methoxy-6-[(E)-(1S,2R,5R)-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-6-phenylsulfanyl-hex-3-enyl]-3,5-dimethyl-tetrahydro-pyran

: 156414-47-0
(2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

Guidance literature:: With Oxone; pH₄ buffer; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)73057-7

Reference yield:

: 2121-69-9,54630-82-9,107173-22-8,3817-48-9
(2R,4S)-2,4-dimethylpentane-1,5-diol

: 156414-47-0
(2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 17 steps

1: porcine pancreatic lipase on celite

2: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 - 25 °C

3: n-BuLi / tetrahydrofuran / 0 °C

4: 3N NaOH, Bu₄NOH / H₂O; tetrahydrofuran / 60 °C

5: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 - 25 °C

6: CH₂Cl₂

7: 98 percent / H₂O₂, DHP / tetrahydrofuran

8: 1.) O₃; 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C; 2.) -78 deg C -> 25 deg C

9: 90 percent / toluene; tetrahydrofuran / -78 °C

10: 88 percent / Zn, H₂O / methanol

11: 99 percent / NaH / tetrahydrofuran

12: 1.) O₃; 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 --> 25 deg C

13: 49 percent / CrCl₂, NiCl₂, DMSO

14: 75 percent / NaH, NaI / tetrahydrofuran / 0 - 25 °C

15: 84 percent / Amberlyst 15 / methanol

16: 85 percent / Bu₃P / benzene

17: 93 percent / Oxone, pH₄ buffer, / tetrahydrofuran; methanol

With 3,4-dihydro-2H-pyran; chromium dichloride; Oxone; sodium hydroxide; n-butyllithium; Amberlyst 15; oxalyl dichloride; tributylphosphine; pH₄ buffer; porcine pancreatic lipase on Celite; tetra(n-butyl)ammonium hydroxide; water; dihydrogen peroxide; sodium hydride; ozone; dimethyl sulfoxide; triethylamine; triphenylphosphine; sodium iodide; nickel dichloride; zinc; In tetrahydrofuran; methanol; dichloromethane; water; toluene; benzene;
DOI:10.1016/S0040-4039(00)73057-7

Reference yield:

: 90270-02-3,97937-36-5
(2R,4S)-1-hydroxy-2,4-dimethylpentyl acetate

: 156414-47-0
(2R,3R,5S,6R)-2-[(E)-(1S,2R,5R)-6-Benzenesulfonyl-1-methoxy-2-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-3-enyl]-6-methoxy-3,5-dimethyl-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 16 steps

1: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 - 25 °C

2: n-BuLi / tetrahydrofuran / 0 °C

3: 3N NaOH, Bu₄NOH / H₂O; tetrahydrofuran / 60 °C

4: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 - 25 °C

5: CH₂Cl₂

6: 98 percent / H₂O₂, DHP / tetrahydrofuran

7: 1.) O₃; 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C; 2.) -78 deg C -> 25 deg C

8: 90 percent / toluene; tetrahydrofuran / -78 °C

9: 88 percent / Zn, H₂O / methanol

10: 99 percent / NaH / tetrahydrofuran

11: 1.) O₃; 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 --> 25 deg C

12: 49 percent / CrCl₂, NiCl₂, DMSO

13: 75 percent / NaH, NaI / tetrahydrofuran / 0 - 25 °C

14: 84 percent / Amberlyst 15 / methanol

15: 85 percent / Bu₃P / benzene

16: 93 percent / Oxone, pH₄ buffer, / tetrahydrofuran; methanol

With 3,4-dihydro-2H-pyran; chromium dichloride; Oxone; sodium hydroxide; n-butyllithium; Amberlyst 15; oxalyl dichloride; tributylphosphine; pH₄ buffer; tetra(n-butyl)ammonium hydroxide; water; dihydrogen peroxide; sodium hydride; ozone; dimethyl sulfoxide; triethylamine; triphenylphosphine; sodium iodide; nickel dichloride; zinc; In tetrahydrofuran; methanol; dichloromethane; water; toluene; benzene;
DOI:10.1016/S0040-4039(00)73057-7