(1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

Base Information

Chemical Name:(1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol
CAS No.:444926-68-5
Molecular Formula:C₂₈H₄₆O₃
Molecular Weight:430.671
Hs Code.:

Synonyms:(1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

Suppliers and Price of (1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

There total 15 articles about (1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 444926-66-3
(1R,3aS,4S,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-hexahydro-indene-2,5-dione

: 444926-68-5
(1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1021/jo020103v

Reference yield:

: 276244-50-9
C₂₁H₃₄O₃

: 444926-68-5
(1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

Guidance literature:: Multi-step reaction with 12 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 14 percent Turnov_. / tetrahydrofuran / -78 - 20 °C

2.1: triethyl orthoformate; p-TsOH*H₂O / CH₂Cl₂ / 72 h / 20 °C

2.2: 18 percent / p-TsOH*H₂O / ethanol / 48 h / 20 °C

3.1: 86 percent / triethyl orthoformate; p-TsOH*H₂O / CH₂Cl₂ / 72 h / 20 °C

4.1: 86 percent Turnov_. / pyridine / CH₂Cl₂ / 0 - 20 °C

5.1: 89 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 88 percent / tetrahydrofuran; hexane / 7.5 h / -78 - 20 °C

7.1: 43 mg / Na; EtOH / tetrahydrofuran / 2 h / -20 °C

8.1: 34 mg / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h / 20 °C

9.1: tetrahydrofuran / 0 °C

9.2: 17 percent / HCl / tetrahydrofuran; methanol; H₂O / 4.5 h / Heating

10.1: 69 percent Turnov_. / KI / acetic acid / 48 h / 20 °C

11.1: CuI / diethyl ether / 1 h / -20 °C

11.2: 66 percent / diethyl ether / 1 h / -20 °C

12.1: 45 percent / L-Selectride / tetrahydrofuran / 2 h / -78 - 20 °C

With pyridine; copper(l) iodide; n-butyllithium; ethanol; sodium; L-Selectride; diisobutylaluminium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; orthoformic acid triethyl ester; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid; 8.1: Dess-Martin reaction;
DOI:10.1021/jo020103v

Reference yield:

: 444926-42-5
C₂₄H₃₈O₅

: 444926-68-5
(1R,2S,3aS,4S,5R,7aS)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-indene-2,5-diol

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethyl orthoformate; p-TsOH*H₂O / CH₂Cl₂ / 72 h / 20 °C

1.2: 18 percent / p-TsOH*H₂O / ethanol / 48 h / 20 °C

2.1: 86 percent / triethyl orthoformate; p-TsOH*H₂O / CH₂Cl₂ / 72 h / 20 °C

3.1: 86 percent Turnov_. / pyridine / CH₂Cl₂ / 0 - 20 °C

4.1: 89 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 88 percent / tetrahydrofuran; hexane / 7.5 h / -78 - 20 °C

6.1: 43 mg / Na; EtOH / tetrahydrofuran / 2 h / -20 °C

7.1: 34 mg / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h / 20 °C

8.1: tetrahydrofuran / 0 °C

8.2: 17 percent / HCl / tetrahydrofuran; methanol; H₂O / 4.5 h / Heating

9.1: 69 percent Turnov_. / KI / acetic acid / 48 h / 20 °C

10.1: CuI / diethyl ether / 1 h / -20 °C

10.2: 66 percent / diethyl ether / 1 h / -20 °C

11.1: 45 percent / L-Selectride / tetrahydrofuran / 2 h / -78 - 20 °C

With pyridine; copper(l) iodide; n-butyllithium; ethanol; sodium; L-Selectride; diisobutylaluminium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; orthoformic acid triethyl ester; potassium iodide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid; 7.1: Dess-Martin reaction;
DOI:10.1021/jo020103v