propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

Base Information

Chemical Name:propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate
CAS No.:1319745-65-7
Molecular Formula:C₁₉H₂₂O₆S
Molecular Weight:378.446
Hs Code.:

Synonyms:propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

Suppliers and Price of propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

There total 5 articles about propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1198790-98-5
sodium (1R,4S,5R)-1,4,5-trihydroxy-3-[(benzo[b]thiophen-5-yl)methoxy]cyclohex-2-en-1-carboxylate

: 106-94-5
propyl bromide

: 1319745-65-7
propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

Guidance literature:: sodium (1R,4S,5R)-1,4,5-trihydroxy-3-[(benzo[b]thiophen-5-yl)methoxy]cyclohex-2-en-1-carboxylate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

propyl bromide; In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/jm2006063

Reference yield:

: 1198791-10-4
(1R,4S,5R)-3-(benzo[b]tiophen-5-yl)methoxy-1,4-dihydroxy-cyclohex-2-en-1,5-carbolactone

: 1319745-65-7
propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h

With potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2006063

Reference yield:

: 862791-12-6
(1R,4S,5R)-1,4-bis(tert-butyldimethylsilyloxy)-3-oxocyclohexane-1,5-carbolactone

: 1319745-65-7
propyl (1R,4S,5R)-3-(benzo[b]thiophen-5-yl)methoxy-1,4,5-trihydroxycyclohex-2-ene-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / N,N-dimethyl-formamide; toluene / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

3.1: sodium hydroxide / tetrahydrofuran / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 2 h

With tetrabutyl ammonium fluoride; potassium hexamethylsilazane; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2006063