[((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

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Chemical Name:[((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid
CAS No.:108269-72-3
Molecular Formula:C₂HF₃O₂*C₂₆H₃₄N₄O₇S
Molecular Weight:660.669
Hs Code.:

[((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

Synonyms:[((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

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Chemical Property of [((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

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Technology Process of [((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

There total 5 articles about [((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100572-39-2
N^α-Boc-Tyr-D-Met-Phe-OH

: 108269-72-3
[((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 2 h, b ) RT, 24 h

2: 81 percent / 1 N NaOH / methanol; H₂O / 2 h / Ambient temperature

3: 83 percent / 11.2 M H₂O₂ / acetic acid / 1 h / 20 °C

4: 90 percent aq. TFA, anisole / 0.67 h

With sodium hydroxide; dihydrogen peroxide; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00392a002

Reference yield:

: C₃₃H₄₅N₃O₈S

: 108269-72-3
[((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / dimethylformamide / a) -10 deg C, 1 h, b) from 0 deg C to 10 deg C, 3 h

2: 81 percent / 1 N NaOH / methanol; H₂O / 2 h / Ambient temperature

3: 83 percent / 11.2 M H₂O₂ / acetic acid / 1 h / 20 °C

4: 90 percent aq. TFA, anisole / 0.67 h

With 4-methyl-morpholine; sodium hydroxide; dihydrogen peroxide; methoxybenzene; trifluoroacetic acid; In methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00392a002

Reference yield:

: 108269-49-4
Boc-Tyr-D-Met-Phe-Sar-OCH₃

: 108269-72-3
[((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methanesulfinyl-butyrylamino}-3-phenyl-propionyl)-methyl-amino]-acetic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 1 N NaOH / methanol; H₂O / 2 h / Ambient temperature

2: 83 percent / 11.2 M H₂O₂ / acetic acid / 1 h / 20 °C

3: 90 percent aq. TFA, anisole / 0.67 h

With sodium hydroxide; dihydrogen peroxide; methoxybenzene; trifluoroacetic acid; In methanol; water; acetic acid;
DOI:10.1021/jm00392a002