Acetic acid,2-[(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)thio]-,2-[(2-hydroxyphenyl)methylene]hydrazide

Base Information

• Chemical Name: Acetic acid,2-[(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)thio]-,2-[(2-hydroxyphenyl)methylene]hydrazide
• CAS No.: 143212-86-6
• Molecular Formula: C₁₄H₁₃N₇O₂S
• Molecular Weight: 343.369
• Mol file: 143212-86-6.mol

Synonyms:Aceticacid, [(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)thio]-,[(2-hydroxyphenyl)methylene]hydrazide (9CI); [1,2,4]Triazolo[1,5-c]pyrimidine,acetic acid deriv.

Chemical Property of Acetic acid,2-[(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)thio]-,2-[(2-hydroxyphenyl)methylene]hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.61g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid,2-[(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)thio]-,2-[(2-hydroxyphenyl)methylene]hydrazide

There total 3 articles about Acetic acid,2-[(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)thio]-,2-[(2-hydroxyphenyl)methylene]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

salicylaldehyde (90-02-8) + (7-amino-s-triazole<1,5-c>yrimidyl-5)thioacetic acid hydrazide (143212-84-4) → (7-Amino-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylsulfanyl)-acetic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (143212-86-6)

Guidance literature:

In ethanol; water; for 2h; Heating;

DOI:10.1007/BF00766451

Reference yield:

7-Amino<1,2,4>triazolo<1,5-c>pyrimidine-5(6H)-thione (70182-88-6) → (7-Amino-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylsulfanyl)-acetic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (143212-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / EtONa / ethanol / 3 h / Heating

2: 90 percent / H₂NNH₂ / ethanol; H₂O; diethyl ether / 0.5 h / Ambient temperature

3: 76 percent / ethanol; H₂O / 2 h / Heating

With sodium ethanolate; hydrazine; In diethyl ether; ethanol; water;

DOI:10.1007/BF00766451

Reference yield:

ethyl (7-amino-s-triazole<1,5-c>pyrimidyl-5)thioacetate (143212-80-0) → (7-Amino-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylsulfanyl)-acetic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (143212-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂NNH₂ / ethanol; H₂O; diethyl ether / 0.5 h / Ambient temperature

2: 76 percent / ethanol; H₂O / 2 h / Heating

With hydrazine; In diethyl ether; ethanol; water;

DOI:10.1007/BF00766451

upstream raw materials:

salicylaldehyde

(7-amino-s-triazole<1,5-c>yrimidyl-5)thioacetic acid hydrazide

7-Amino<1,2,4>triazolo<1,5-c>pyrimidine-5(6H)-thione

ethyl (7-amino-s-triazole<1,5-c>pyrimidyl-5)thioacetate