C₂₃H₂₂BrN₃O₄

Base Information

• Chemical Name: C₂₃H₂₂BrN₃O₄
• CAS No.: 1613056-66-8
• Molecular Formula: C₂₃H₂₂BrN₃O₄
• Molecular Weight: 484.349
• Mol file: 1613056-66-8.mol

Synonyms:C₂₃H₂₂BrN₃O₄

Chemical Property of C₂₃H₂₂BrN₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₂BrN₃O₄

There total 4 articles about C₂₃H₂₂BrN₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C13H13BrN2O (1612853-81-2) + (S)-2-((methoxycarbonyl)amino)-2-phenylacetic acid (60725-19-1) → C23H22BrN3O4 (1613056-66-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield:

N-Benzyloxycarbonyl-L-proline (1148-11-4) → C23H22BrN3O4 (1613056-66-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium chloride / tetrahydrofuran / 30 - 70 °C / Inert atmosphere; Sealed tube

1.2: 30 °C / Inert atmosphere; Sealed tube

2.1: acetic acid / toluene / 6 h / Inert atmosphere; Sealed tube; Reflux

2.2: 1.5 h / 235 °C / Inert atmosphere; Sealed tube

3.1: palladium on activated charcoal; hydrogen / methanol / 5 h / 40 °C / 7600.51 Torr / Inert atmosphere; Sealed tube

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Sealed tube

With palladium on activated charcoal; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; magnesium chloride; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

(S)-benzyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate (1357258-78-6) → C23H22BrN3O4 (1613056-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / toluene / 6 h / Inert atmosphere; Sealed tube; Reflux

1.2: 1.5 h / 235 °C / Inert atmosphere; Sealed tube

2.1: palladium on activated charcoal; hydrogen / methanol / 5 h / 40 °C / 7600.51 Torr / Inert atmosphere; Sealed tube

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Sealed tube

With palladium on activated charcoal; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene;

upstream raw materials:

N-Benzyloxycarbonyl-L-proline

(S)-benzyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate

C₂₁H₁₉BrN₂O₃

C₁₃H₁₃BrN₂O

Downstream raw materials:

C₂₉H₃₄BN₃O₆

C₅₈H₅₇N₇O₇