diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate

Base Information

Chemical Name:diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate
CAS No.:724477-61-6
Molecular Formula:C₁₅H₂₁N₂O₅P
Molecular Weight:340.316
Hs Code.:

Synonyms:diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate

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Chemical Property of diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate

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Technology Process of diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate

There total 1 articles about diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 530100-85-7
(4R)-diethyl 4-hydroxy-2-oxo-4-(4-methylphenyl)butylphosphonate

: 724477-61-6
diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate

Guidance literature:: With 4-toluenesulfonyl azide; potassium carbonate; In acetonitrile; at 0 ℃; for 1.5h;
DOI:10.1002/ejoc.200400018

Reference yield: 97.0%

: 724477-61-6
diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate

: 724477-72-9
(5R)-2-diethoxyphosphoryl-5-(4-methylphenyl)-3-oxotetrahydrofuran

Guidance literature:: With rhodium(II) acetate; In benzene; for 0.5h; Heating;
DOI:10.1002/ejoc.200400018

Reference yield:

: 724477-61-6
diethyl (4R)-1-diazo-4-hydroxy-4-(4-methylphenyl)-2-oxobutylphosphonate

: (5R)-2-(1-methylethylidene)-5-(4-methylphenyl)-3-oxotetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / rhodium(II) acetate / benzene / 0.5 h / Heating

2: 59 percent / K₂CO₃ / H₂O / 2 h / Heating

With rhodium(II) acetate; potassium carbonate; In water; benzene; 2: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/ejoc.200400018