(3S)-3-BOC-AMINO-1-DIAZO-2-BUTANONE

Base Information

Chemical Name:(3S)-3-BOC-AMINO-1-DIAZO-2-BUTANONE
CAS No.:186521-98-2
Molecular Formula:C9H15 N3 O3
Molecular Weight:213.236
Hs Code.:
Mol file:186521-98-2.mol

Synonyms:N-ALPHA-TERT-BUTYLOXYCARBONYL-L-ALANINYL-DIAZOMETHANE;BOC-L-ALA-CHN2;(3S)-3-BOC-AMINO-1-DIAZO-2-BUTANONE

Suppliers and Price of (3S)-3-BOC-AMINO-1-DIAZO-2-BUTANONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (3S)-3-BOC-AMINO-1-DIAZO-2-BUTANONE

Chemical Property:

PSA：92.79000
LogP:1.24126

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S)-3-BOC-AMINO-1-DIAZO-2-BUTANONE

There total 7 articles about (3S)-3-BOC-AMINO-1-DIAZO-2-BUTANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 3744-87-4,7764-95-6,15761-38-3
Boc-(R)-Ala

: 18107-18-1
diazomethyl-trimethyl-silane

: 186521-98-2
N-[(1R)-3-diazo-1-methyl-2-oxopropyl]carbamic acid tert-butyl ester

Guidance literature:: Boc-(R)-Ala; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 2h;

diazomethyl-trimethyl-silane; In tetrahydrofuran; hexane; acetonitrile; at 0 - 20 ℃; for 20h;

Reference yield: 52.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 954143-61-4
(R)-2-tert-butoxycarbonylaminopropionyl chloride

: 186521-98-2
N-[(1R)-3-diazo-1-methyl-2-oxopropyl]carbamic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; diethyl ether; at 20 ℃; for 2.5h;
DOI:10.1021/acs.jmedchem.0c02036

Reference yield:

: 3744-87-4,7764-95-6,15761-38-3
Boc-(R)-Ala

: 186521-98-2
N-[(1R)-3-diazo-1-methyl-2-oxopropyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -30 °C

2: diethyl ether / 0 °C

In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0960-894X(02)00212-3