(5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

Base Information

Chemical Name:(5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol
CAS No.:1404098-90-3
Molecular Formula:C₂₃H₄₂O₃Si₂
Molecular Weight:422.756
Hs Code.:

Synonyms:(5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

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Chemical Property of (5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

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Technology Process of (5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

There total 2 articles about (5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1404098-74-3
(2S,3S)-3-(dimethyl(phenyl)silyl)-1-methoxyhex-4-yn-2-ol

: 192064-71-4
(E)-5-(trimethylsilanyl)pent-4-en-1-ol

: 1404098-90-3
(5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

: 1404099-02-0
(5R,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

Guidance literature:: (2S,3S)-3-(dimethyl(phenyl)silyl)-1-methoxyhex-4-yn-2-ol; With triisopropoxytitanium(IV) chloride; n-butyllithium; cyclopentylmagnesium chloride; In diethyl ether; hexane; at -78 - 0 ℃; for 4h; Inert atmosphere;

(E)-5-(trimethylsilanyl)pent-4-en-1-ol; With n-butyllithium; In diethyl ether; hexane; at -78 - 0 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja3083945

Reference yield:

: 674335-98-9
((2S,3S)-3-Methoxymethyl-oxiranyl)-dimethyl-phenyl-silane

: 1404098-90-3
(5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

: 1404099-02-0
(5R,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diethylaluminium chloride / pentane / 0 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; cyclopentylmagnesium chloride; triisopropoxytitanium(IV) chloride / diethyl ether; hexane / 4 h / -78 - 0 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

With triisopropoxytitanium(IV) chloride; n-butyllithium; diethylaluminium chloride; cyclopentylmagnesium chloride; In diethyl ether; hexane; pentane;
DOI:10.1021/ja3083945

Reference yield: 58.0%

: 1404098-90-3
(5S,8S,9S,E)-5-(dimethyl(phenyl)silyl)-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-ene-1,9-diol

: 1404099-11-1
(5S,8S,9S,E)-8-(dimethyl(phenyl)silyl)-9-hydroxy-10-methoxy-6-methyl-5-(trimethylsilyl)dec-6-enal

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1021/ja3083945